Description

IGF-1 LR3 (1 mg)

High-Purity Research Peptide for IGF-1R Signaling & Binding-Protein Interaction Studies

Product Overview

IGF-1 LR3 (1 mg) is a single-component, research-grade peptide intended for controlled laboratory use in non-clinical settings. IGF-1 LR3 is commonly described as an IGF-1 analog incorporating an Arg (R) substitution at position 3 and a 13-amino-acid N-terminal extension, yielding an 83-amino-acid peptide designed to exhibit markedly reduced affinity for IGF binding proteins (IGFBPs) compared to native IGF-1. This material is positioned for IGF-1R pathway interrogation, assay development, and analytical method work where traceability and reproducibility are required. IGF-1R signaling is widely associated with intracellular cascades such as PI3K-AKT and RAS-MAPK in research literature.

Composition

• Active Ingredient: IGF-1 LR3 – 1 mg (1,000 mcg)

• Form: Lyophilized powder

• Appearance: White/off-white lyophilized cake or powder in a sealed research vial

• Peptide Length: 83 amino acids (commonly cited for LR3 analog)

• Purity: (HPLC/LC-MS COA pending)

• Packaging: Tamper-evident seal with lot number and test date

Research Applications (Non-Clinical)

Suitable for analytical, in-vitro, and pre-validation research such as:

• IGF-1R (IGF-1 receptor) signaling pathway studies and mechanistic modeling

• Comparative work examining IGFBP interaction / reduced IGFBP binding behavior vs native IGF-1 (LR3-type analog rationale)

• PI3K/AKT and RAS/MAPK (MAPK/ERK) cascade interrogation in cell-based systems

• Assay development (ELISA optimization, bioassay calibration, reference standard use)

• Analytical confirmation (identity, purity, chromatographic resolution, impurity profiling via HPLC/LC-MS)

• Stability profiling of lyophilized peptide under controlled environmental conditions

Documentation & Traceability

• Lot-specific Certificate of Analysis (COA) pending

• Batch traceability to support internal QA review and scientific auditing

• Time-stamped lot validation records (per lot documentation)

Quality & Manufacturing

• Produced under a quality-managed system aligned with ISO-based process controls and cGMP-informed handling practices

• Lyophilized format supports improved stability during transit and storage

• No MOQ required for standard online orders (if applicable to your store rules)

• Bulk institutional purchases available (if applicable to your program)

Storage & Handling Guidelines

Unreconstituted Vials

• Store cold, dry, and protected from light

• Recommended long-term storage: ≤ −20 °C (best practice: −80 °C for extended preservation)

• Avoid moisture exposure and repeated temperature cycling

After reconstitution (research use only)

• Reconstitute using an appropriate sterile solvent suitable for your assay design (commonly sterile water or buffered/acidified solutions used in protein work; select based on method requirements)

• Store 2–8 °C for short-term use; for longer storage, aliquot and freeze (−20 °C to −80 °C)

• Avoid repeated freeze-thaw cycles (use aliquots)

Compliance Statement

⚠️ Important Notice: For research use only. Not for human consumption. Not for diagnostic or therapeutic applications. Not intended to diagnose, treat, cure, or prevent any disease. Use restricted to qualified laboratory professionals in controlled settings.

Legal Disclaimer

All MNM ProLabs Research Peptides are distributed exclusively for laboratory testing, assay development, and in-vitro research applications. These materials are not approved for human or veterinary administration. Purchasers assume full responsibility for safe handling, storage, and regulatory compliance in accordance with all local, state, and federal guidelines.